Kayla Tougas L&S Biological Sciences
Hypothalamic Regulation of Blood Volume Expansion During Pregnancy
The hypothalamus of the brain regulates critical parameters such as fluid balance. Fluid balance is the equilibrium between water intake and output, and is measured in the body as blood volume and blood osmolality. Fluid balance is regulated by behaviors such as thirst. The lamina terminalis of the hypothalamus regulates thirst, and is therefore essential for maintaining fluid balance.
During pregnancy, female physiology undergoes dramatic changes. Notably, maternal blood volume increases by 30-50% to support fetal growth. An insufficient increase can lead to severe conditions like preeclampsia. Though it is known how the kidneys and blood vessels contribute to expanding blood volume during pregnancy, our knowledge of how the brain is involved remains understudied.
My project will examine the neuronal activation of the lamina terminalis during pregnancy to assess its role in regulating fluid balance. Ultimately, this project lays the foundation for increasing our knowledge of how the brain works during pregnancy. It has the potential to lead to treatments for devastating pregnancy complications, including preeclampsia.
Message To Sponsor
Thank you so much for sponsoring my summer research project! I am really passionate about bridging gaps in women's health. Your generous support will bring me closer to this goal by allowing me to pursue these critical unknowns.