Alix Mary Lacoste L&S Sciences
The role of IGF signaling in cell migration and axon guidance in the developing mouse cerebellum
Growth factors are not traditionally known to play a role in cell migration. However, preliminary data suggest that insulin-like growth factor (Igf) functions in the guidance of granule cells within the cerebellum. The cerebellum is an important structure, responsible for the fine control of balance and movement and also involved in motor learning and memory. The cerebellar granule cell is the most abundant neuron in the brain, and investigating its development and wiring could provide insights into the functioning of the cerebellum and into diseases that affect its function. Using modern genetic techniques, my research approach is to conditionally inactivate the Igf1 receptor in mice cerebella. I will then assay for aberrant granule cell localization and axon pathfinding in these mutant mice.