Ashley Nicole Lipps Humanities and Social Science
Osteoarthritis and Osteophytosis : a comparative study of Aging in the Rhesus Macaque (Macaca mulatta)
Age-related bone loss and osteoarthritis have been exhibited in several mammalian species, and both are especially common in humans. However, the etiology behind age-related bone loss is highly complicated and osteoarthritis is especially unstudied. Previous studies have relied on rodent models and have primarily investigated changes in BMD (Bone Mineral Density); however several weaknesses are associated with both approaches. I will be using Macaca mulatta, a similar species to humans with analogous bone remodeling processes in both cancellous and cortical bone. I will be using two methods: 1) histomorphometric analysis of rib microstructure and 2) physical scoring of vertebral osteoarthritis and osteophytosis. My analysis will thoroughly track the progression of bone loss and disease from maturation to old age.