Bryan Castillo-Rojas Rose Hills
Investigating Flavivirus NS1's Role in Facilitating Viral Dissemination
Dengue virus (DENV) is a vector-borne virus that is transmitted by Aedes mosquitoes. Typically found in tropical and sub-tropical regions in the world, DENV can cause mild disease manifestations like dengue fever; however, cases of severe dengue disease exist and are characterized by vascular leakage and shock, which is triggered by virus infection and an overactive immune response. Medically important viruses like flaviviruses (dengue, Zika, West Nile, and yellow fever viruses, etc.) must disseminate from the initial site of infection into diverse tissues throughout the body to cause disease. Therefore, my summer research project will focus on the role of dengue virus NS1-mediated leak in virus infection and dissemination in vivo.