Bryce Jarman Rose Hills
Mechanistic Study of a Bioorthogonal Oxidative Coupling Reaction
The goal of my research project is to study a new method of bioconjugation: an oxidant mediated coupling reaction. This reaction is highly site specific and unreactive with the functional groups traditionally found in biological systems, making it useful for the efficient construction of biomaterials with a variety of different functions. Although this reaction has already seen a variety of uses, further studies into the mechanism will allow for even greater tuning of the reactions selectivity and efficiency. To do this I will prepare a set of internal standards and then use these standards as a basis for a series of high throughput screens that will analyze a variety of different components of the reaction. Ideally, some of the information gathered will pave the way for a set of low temperature NMR studies that, when combined with other information gathered in the screens, will provide insight into the reaction mechanism.