Chung Yan Cheung L&S Sciences
Developmental role of Gremlin2 in the Mouse Dorsal Spinal Cord
Development of the nervous system depends on the migration, differentiation, and axonal projections of neurons to their appropriate targets. In the dorsal spinal cord where many sensory and interneurons are born, signaling cues specify the development of neuronal precursors into an array of cell types. However, the process by which these signals regulate neuronal growth is still unclear. This summer, I will examine the function of the Gremlin2 gene, which is expressed in a specific population of dorsal interneurons. Taking advantage of Gremlin2 knock-out mice, I will use immunocytochemistry to determine the precise anatomical location of Gremlin2 expression and analyze defects in specification, migration, and connectivity of these interneurons.