Emily Duan L&S Sciences
Understanding the Effect of a Necroptotic Cancer Vaccine on Anti-tumor Immunity
The activation of the adaptive immune system in host-tumor interaction mediates the efficiency and strength of the host anti-tumor response. Necroptosis, a form of programmed cell death, has the ability to moderate the development of antitumor tolerance versus immunity due to its pro-inflammatory properties. However, in what ways and to what extent do the products of necroptosis trigger the activation of the immune system is not well understood. I am interested in using a necroptotic tumor vaccine overexpressing RIP3, a cell death protein, to study the effect of necroptosis on the adaptive immune systems ability to detect and fight cancer cells. Through transduction of cancer cell lines, tumor injections in mice, and flow cytometry, I will investigate the effect of a necroptotic vaccine on the adaptive immune systems tumor response by characterizing APC and T-cell function.