Henry Lee L&S Biological Sciences
Exploring Degradation of Whisker-Mediated Spatial Tuning in Scn2A Mice
Atypical sensory experience, such as being hyper- or hypo-sensitive, affects about 90% of individuals with autism spectrum disorders (ASD). Yet, the mechanisms behind ASD’s effect on sensory perception are not well understood. Recent research in several mouse models for ASD showed a relationship between the presence of ASD related genes and abnormal sensory tuning. In mice with a mutation in the Scn2A gene, the maps in the brain that process touch information become blurred and overlap. This suggests that while a mouse might be able to detect objects, they may struggle to discriminate between different objects. By developing a novel touch-based task and using high-density electrode grids to record brain activity with millisecond precision, I aim to quantitatively link these blurred brain maps to specific behavioral outcomes. This work will help us understand the circuit-level origins of sensory symptoms in ASD, providing a vital framework for understanding how genetic changes translate into unique sensory experiences.
Message To Sponsor
I am incredibly grateful for your support of my research into the neural mechanisms of Autism Spectrum Disorder. My ultimate goal is to understand mental disorders as a collection of objective biological markers. Due to your generous support, I am able to use advanced techniques to bridge the gap between genetics and observable behavior. Thank you for making my exploration into the complexities of the brain possible.