Jane Yu L&S Sciences
A Novel Gene Affects Cartilage Patterning and Joint Formation in Mice
We are studying the role that a gene called KST245 plays in joint formation in mice. Currently, little is known about the regulation of joint development in the field of skeletal biology. However, through our research we hope to advance the field and share information that may be important in treating poorly understood joint diseases, such as arthritis. Mice that lack the functional KST245 gene (KST245 mutants) show irregular cartilage growth and misplaced joints. By examining the differences between the KST245 mutants and unaltered mice, we hope to understand the specific functions of this gene. To do so, we will compare differences in expression of related genes, cell growth and death, and tissue formation.