Kayleigh Cook Rose Hills
Role of GPR183 in EET-signaling
My project centers on epoxyeicosatrienoic acids (EETs) which are located in endothelial and vascular smooth muscle cells. From previous studies, they have been shown to be potent vasodilators and though the receptor is not known, their mechanism is believed to rely on calcium activated potassium channels and the hyperpolarization of smooth muscle. In addition to vasodilation, EETs are known to help maintain cardiovascular homeostasis through anti-inflammatory effects and can protect against ischemia and hypertension. Discovering the receptors that control the potential benefits of EETs could lead to new therapeutic options for patients with cardiovascular disease. Based on my preliminary studies using a transfection-based screening strategy in a line of cells expressing fluorescent calcium sensors, my hypothesis is that GPR183 is the receptor through which EET mediates vascular relaxation.