Leo Porter-Zasada Rose Hills
Synthesis of a Homochiral MetalOrganic Framework
In this project, I will attempt to create a less expensive and more effective method to synthesize and separate chiral compounds in large quantities. Because a large percentage of biological molecules are chiral (i.e. they have non-superimposable mirror images), many bioactive and pharmaceutical compounds are also chiral, and separations and synthesis of these chiral compounds is a pivotal challenge in pharmaceutical research. To address this challenge, I aim to create an enantiopure chiral metalorganic framework (MOF) by introducing chiral additives during synthesis to induce bulk homochirality. Preliminary findings indicate this MOF could potentially be useful for separating chiral molecules or for synthesizing enantiopure molecules directly in a catalytic reaction.