Lusha Liang L&S Sciences
Why Are Gene Regulators and Their Targets Co-localized in the Bacterial Genome?
In bacterial genomes, functionally related genes tend to be grouped together in operons, possibly to facilitate co-regulation and coordinated horizontal gene transfer. However, co-regulation and the formation of selfish gene clusters cannot explain the co-localization of regulators and their target operons. Yet this co-localization of prokaryotic transcription factor genes and their binding sites is widespread and is a driving force in the specific organization of transcriptional units on the chromosome. Thus in this study I will use the paradigmatic model of gene regulation, the lac locus, to address a fundamental question: why are gene regulators and their targets co-localized in bacterial genomes?