Michael Yi Rose Hills
Synthesis and Testing of Porous, Sulfonated Polymer Systems for Drug Capture
Chemotherapy is one of the most widely known treatments for cancer, both for its effectiveness yet fatal side effects. Doxorubicin, a common type of chemotherapy drug, has the ability to kill malignant tumor cells, but is limited by the harmful interactions excess molecules cause towards human tissue. Various resins and activated carbons are being tested for drug capturing mechanisms, as many drug molecules are shown to have high binding capacities towards them. Doxorubicin, however, is more complex due to its ionic nature, and requires the use of ion exchange and charged systems. My research project will focus on utilizing negatively charged sulfonated polymer membranes for incorporation into Doxorubicin drug capture. I will test the drug uptake by these polymers in aqueous solutions and blood through intensity measurements from fluorescence spectroscopy. Various flow models will be used in order to accurately model the human bloodstream. My goal will be developing a model to describe the drug capturing kinetics and mass transport phenomena for Doxorubicin binding interactions with these sulfonated polymers.