Robert Saxton Rose Hills
Regulated Degradation of KIF20A by the APC/C
The Anaphase Promoting Complex/Cyclosome (APC/C) is an essential protein that allows cells to divide in a timely and proper manner. Inhibition of the APC/C prevents proper cell division, making it a protein of interest for cancer therapies. While many targets of the APC have been identified, its full spectrum of substrates is not yet characterized. In this project, I will be studying the interaction between the APC and a proposed novel substrate, KIF20A, a motor protein that is also essential for cell division, and which is also of interest in the development of future cancer therapies. In studying the interaction between these two proteins, I hope to identify and characterize a novel APC substrate, and to potentially discover new mechanisms of APC/C regulation. Ultimately, this project will help to gain a deeper understanding into how this crucial protein complex regulates cell division.