Rylee Chaisongkram Rose Hills
Effects of Stress on Reproductive Health via Kisspeptin Neurons
Over generations, there has been a steady decline in reproductive rates. One in 6 adults across the world experience infertility, with stress contributing substantially to this decline. While studies highlight stress-related health risks, its specific impact on the reproductive system at the brain level remains unclear. This project will explore the connection between stress and the neuroendocrine regulation of female reproductive function, with a particular focus on kisspeptin (Kp) neurons in the posterodorsal medial amygdala (MePD) region of the brain. Through the use of transgenic mouse models, immunohistochemistry, and viral tract tracing, I will determine how exposure to stress affects the activity of Kp neurons in the MePD and identify the possible downstream targets that involve in stress-induced suppression of the reproductive system. These findings intend to bridge the gap between the impact of stress on female neuroendocrine mechanisms which influence reproductive health.
Message To Sponsor
Thank you so much for making this project possible. Having the privilege to focus on research this summer has enabled me to expand my capabilities within the lab and enhance the depth of my research. I am so excited to continue collaborating with amazing people at UC Berkeley in hopes of making impactful contributions to the field of Neuroscience. Your support is deeply appreciated.