Shila Manandhar L&S Sciences
Neurogenesis from Neuroglia
Neurogenesis, the process by which new neurons form, was thought to be impossible in mature brains for most of the 20th century. However, recent studies have found that neurogenesis in intact adult brains does occur in specific regions. I will be studying neurogenesis in vitro using neuroglial cells, which are neuron supporting cells, by treating them with Epidermal Growth Factor (EGF) and Fibroblast Growth Factor (FGF). Following treatment, I will perform functional tests to evaluate the extent to which these factors were able to promote the transdifferentiation of these neuroglial cells into functional neurons. Learning the pathway to inducing neurogenesis could ultimately lead to important implications for the treatments of countless neurodegenerative diseases, such as Alzheimers and Parkinsons disease.