Xiao Hua Chen Rose Hills
Evaluating Chromatins Role in Sex-Specific Aging with Drosophila Lifespan AssaysDoris Bachtrog
While research concerning the molecular aspects of aging exists, there remain unanswered questions regarding aging differences between males and females. Differences in aging between males and females is a phenomenon that has been observed in many different animals with XY sex determination, including humans. These differences are manifested in the observation that females outlive males. Recent studies have provided insight into the potential role of sex-specific chromatin in aging. My project will focus on conducting lifespan assays for Drosophila flies with altered sex chromosome configurations to directly test the effect of chromatin on aging. By using males that lack a Y chromosome, females with a Y chromosome, and flies with varying degrees of X-linked genomes, I hope to elucidate the influence of Y and X-linked chromatin on sex-specific aging.