Investigating the DNA sensing abilities of TFIID
I have been working in the Nogales Lab through URAP this past academic year with graduate student Avinash Patel. Previous work within the lab has shown that the general transcription factor TFIID binds promoter DNA at two major points: the downstream and upstream regions. Our research aims to understand how the downstream contacts are formed and to discern what the protein components of TFIID are sensing within the downstream promoter. This summer, we will be continuing our research efforts to answer these questions using a combination of biochemical and structural biology methods.