Investigating contributions of KGB-1 to stress resistance
Organisms are continually faced by a variety of external and internal stressors, which often both contribute to and are exacerbated by the aging process and associated pathologies. Our lab uncovered an age-dependent switch in the contributions of the C. elegans JNK protein KGB-1 to stress resistance, providing protection in larvae, but reducing resistance and shortening lifespan in adults. This switch is associated with age-dependent regulation of the longevity and stress resistance associated transcription factor DAF-16/FOXO. I am working to understand the protective effects of KGB-1 and the nature of KGB-1’s interaction(s) with DAF-16, with the goal of improving our understanding of how cellular and organism level stress responses change with age.