Dengue Virus Pathogenesis in a Mouse Model
Dengue virus is one of the most increasingly concerning mosquito-borne diseases that infects almost 400 million individuals annually at tremendous cost to not just afflicted patients but entire healthcare infrastructure systems. My research this coming Summer is a continuation of my work in the Harris lab since Fall 2017 where I have been investigating the role of dengue virus non-structural protein (NS1) on the pathogenesis of the disease. Specifically, my research scope focuses on if NS1-induced vascular leak (one of the main clinical indicators of disease) can be inhibited by monoclonal antibodies or anti-sera targeting NS1 in a mouse model. The hope is that findings from this research initiative will provide preliminary data with the potential for future implications on the development of protective vaccines and therapeutic treatments.