anti-DENV and anti-ZIKV immunity interactions
Dengue and Vika virus are mosquito-borne flaviviruses common in tropical and sub-tropical areas that can result in a range of clinical manifestations, from a self-limited dengue fever to a potentially fatal dengue shock syndrome (DSS) caused by vascular leakage. This summer, I will be researching anti-DENV and anti-ZIKV immunity interactions using a Luminex system to determine which serotypes are correlated with primary inapparent infection of Dengue. My personal focus is on domain III of the envelope protein of DENV 1-4 and ZIKV, a domain known to bind type-specific antibodies. By analyzing the binding profiles of type-specific and cross-reactive antibodies, I will be able to better understand the profiles of a combination of sequential infections, and better predict how to develop and evaluate Dengue and Zika virus vaccines.