Intestinal LRH-1 and the Modulation of Bioacid Metabolism
It is known that bile acids are crucial hormones synthesized by the liver which aid in emulsifying dietary fats, absorption of nutritious vitamins from meals, elimination of waste products such as cholesterol, and controlling energy homeostasis. Previous knowledge thanks to papers by Lee et al. and Miranda et al. indicates that nuclear receptor Liver Receptor Homolog-1 (LRH-1) plays roles in hepatic cholesterol and bile acid control in the liver. Based on this, Bayrer Lab has discovered data suggesting intestinal LRH-1 activity is critical for bile acid homeostasis and balancing energy homeostasis. Thus, one of the projects I will be working on this summer addresses the function of LRH-1 in bile acid transport in the gut intestinal epithelium and how it affects the host glucose and lipid metabolism within the gut-liver axis communication system.