Sum Ying Celeste Wu
Investigating Plekhg2/3 in the African Clawed Frog (Xenopus Laevis)
I aim to continue working on characterizing the Plekhg2 and Plekhg3 gene pathways in African Clawed Frogs (Xenopus laevis), which will aid our understanding in the gastrulation process. Gastrulation gives rise to the ectoderm and endoderm among other structures, and has a marked migration process where cells called bottle cells initiate the “caving in” that forms aforementioned layers. The genes of interest, among others that my lab mentor and I have worked on, are thought to either kickstart or sustain the bottle cell movement. We hope to use our recently completed gene construct to run knockout (mRNA) or rescue experiments which will give us more insight on the bigger picture of gene pathways related to bottle cells and gastrulation.