Chen Kai Huang
The gut microbiota plays a salient role in mediating host physiology and immunity. Several studies link immune checkpoint inhibitor (ICI) efficacy in extraintestinal cancers to gut microbiota composition, with commensals, such as Akkermansia muciniphila (A. muciniphila). Recently, studies found that A. muciniphila treatment during anti-PD1 immunotherapy showed potential clinical relevance; however, the differential effects on antitumor responses by the different strains of A. muciniphila are not yet elucidated. Becken et al. (2021) genotyped 71 strains of A. muciniphila, together representing the Am (A. muciniphila) I, AmII, and AmIV clades, and […]
William Hastings
The characteristics of the orbitofrontal cortex (OFC) and measures of emotionally-related impulsivity (ERI) offer strong diagnostic potential in the identification of internalized and externalized disorders (Nakamura et al., 2020; Johnson et al., 2013). Yet, nearly two dozen papers attempted to locate the neural correlates of ERI with no success (Johnson et al., 2020) until recently, with the discovery of a morphological link between the OFC and measures of ERI (Elliott et al., 2021). Of interest to the present project, separate and prior work identified that the patterning of indentions (sulci) […]
Zia Bajwa
The specific question that my research investigates is how might we better understand and optimize implementation outcomes for a novel transdiagnostic sleep intervention designed for psychiatric populations. More specifically, the goal of this project is to inductively code providers evaluations of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), thus providing important insight into the efficacy of this sleep-focused program’s implementation. This project contributes new knowledge to the field of psychology by attempting to more deeply understand how to properly and effectively implement novel therapies, especially for those with […]
Soobin Hong
Studying learning is crucial to understanding the human mind. Currently, active research is being done on the relationship between cognitive processes and memory systems. While most studies focus on the systems individually, much recent research shows that human learning can be better explained by considering multiple systems simultaneously. We focus on the RLWM framework, which suggests that reinforcement learning (RL) and working memory (WM) both contribute significantly to trial-and-error learning. It takes into account the limited capacity of memory, more efficiently accounting for dependence of learning on the number of […]
Yuming Huang
Geometric flows, such as the Ricci flow, Yang-Mills flow, and harmonic map flow, are natural ways to smooth out geometric objects (metric, connection, and maps, respectively). In this project, we will explore the idea of using geometric flows to develop new analytic tools for studying geometric objects. A possible goal of this project is to use geometric flows to solve problems in dispersive PDEs that involve geometric objects.
Lillie Bui
Sleep is a fundamental aspect of human health. One way that our body regulates sleep is through sleep pressure, the balance between sleep and wakefulness. The dysregulation of sleep pressure is a common occurrence in patients with Parkinson’s disease, manifesting in sleep disturbances such as insomnia or excessive daytime sleepiness. It is undetermined if sleep problems and neurodegeneration have common mechanisms, but one potential area of research is in reactive oxygen species (ROS), which have been implicated in Parkinson’s disease. Emerging evidence indicates that ROS accumulate during steady activity of […]
Julia Huffaker
Dengue virus (DENV) is a viral disease endemic in subtropical and tropical regions that causes one of the most important mosquito-borne viral disease affecting humans, with around 50 million cases annually. Infections are caused by four genetically related but distinct serotypes, DENV1-4, which can lead to individuals becoming infected with multiple serotypes during their lifespan. Primary DENV or ZIKV infections generate antibodies that protect against infection from the same serotype, but they also lead to generation of cross-reactive antibodies that can increase the risk of a secondary symptomatic DENV infection […]
Jatin Batta
Human brains contain ridges (gyri) and indentations (sulci) that other species do not have – especially in evolutionarily expanded neuroanatomical locations, such as association cortices like the lateral prefrontal (LPFC) and lateral parietal cortices (LPC; Zilles et al., 2013; Van Essen, 2007; Voorhies et al., 2021). Indeed, many LPFC and LPC neuroanatomical features are specific to the human brain. For example, recent research has revealed that hominoid-specific tertiary sulci in LPFC serve as functional landmarks (Miller et al., 2021a,b) and their morphological features are predictive of cognition (Voorhies et al., […]
Ashley Blake
Through the bioarchaeological analysis of Medieval Portuguese skeletons, my mentor and I will investigate the relationship between religious burial practices and the preservation of human remains. We will utilize histology to analyze the levels of chemical and physical degradation of bone. Our investigation starts with the macroscopic analysis of the skeletal remains and then the development of microscopic slides to categorize the degree of taphonomic damage. Once prepared, we will gather qualitative and quantitative data for assessment. Our goal is to uncover how different religious communities interacted with death during […]
Lauren Anastasia
What are the purposes, possibilities, and limitations of the traditional gallery space? Through understanding who has been excluded from the gallery, we aim to rethink what an exhibition space can and should be. Through our research, we will stage our own space on campus that subverts gallery conventions. We will present an alternative functionality, proposing that the gallery space should offer tangible assets to its community. Our work is a collaborative art project situated in the history of service labor, endurance art performances, gallery culture, and the history of subversive […]