Undergraduate Research & Scholarships

Emily Zhao

Profile image of Emily Zhao

  Understanding the genetic basis of organ regeneration remains a central challenge in the field of developmental biology. Teeth are a classic model for organogenesis, since many homologous ectodermal organs (e.g., teeth and hair) follow similar patterns of development and regeneration. Threespine stickleback fish are a powerful model organism for studying tooth regeneration in vertebrates because they possess the ancestral dental phenotype of polyphyodonty, in which teeth are continuously replaced throughout adult life. Past research has shown that Foxc1 regulates Bmp6, a gene important for viability, growth, and tooth patterning […]

Xiaozhou Zhang

The perception of a stimulus is strongly influenced by the background surrounding it. In mammals, this figure-ground perception to identify stimuli from the environment is crucial for survival, such as detecting predators. My project aims to explore the neural mechanisms behind figure-ground perception, especially focusing on the role of vasointestinal peptide positive (VIP) and somatostatin (SOM) interneurons in the primary visual cortex (V1). To explore the mechanism, I will first develop a novel mice behavioral task that can accurately quantify figure-ground modulation. Then, I will use optogenetics to activate or […]

Tannya Tang

Profile image of Tannya Tang

In arthropods and vertebrates, Hox genes determine how an organism develops along the axis running from its head to its tail. Little is known of Hox function outside of these standard animal models, but studies in annelids (segmented worms) suggest that Hox genes not only play a conserved role in embryonic patterning, but are also deployed in ways specific to annelids. For example, hox3 is expressed around the posterior growth zone (PGZ), from which all new segments arise. I hypothesize that hox3 is a stem cell marker in annelids that […]

Alexander Toller

Profile image of Alexander Toller

Suppose that we have a (finite or infinite) series of independent, identically distributed real-valued random variables (increments of time). From this series, we can form a random walk. We can consider the partial sums of this series and analyze the average value of the walk the partial sum divided by the number of increments up to that point at each of its time increments. This project is focused on studying the distribution of the maximum average value of a random walk through a variety of computational algorithms. While there already […]

Jiayi Tan

Profile image of Jiayi Tan

People with high level of nearsightedness will have a 5- to 10-fold chance of developing glaucoma, cataract, and sight-threatening diseases such as retinal detachment later in life. Atropine eye drop is one of the most effective therapies for nearsightedness control. I will conduct a small-scaled randomized controlled trial to understand the impact of eye color on the effectiveness of atropine eye drop. Many studies on atropine have focused on Asian populations, and few studies have compared the effect of atropine between Asians and Europeans, who tend to have much lighter […]

Tiffany Tian

Profile image of Tiffany Tian

Up to half of Wilsons disease patients suffer from sleep disorders, including poor sleep quality, REM behavioral disorders (RBD), and cataplexy. However, the neural basis of these symptoms is poorly understood. My project this summer is to determine whether the ATP7B-/- knockout mouse is a good model system for studying the sleep disorders manifested in Wilsons disease, especially in the context of neural pathways involving copper homeostasis. Using automated sleep scoring methods, we will quantify sleep signatures in ATP7B-/- knockout and wildtype control mice. The brain copper changes in recorded […]

Jianxiang Zhang

  Cataract, a clouding of the eye lens, is the leading cause of blindness worldwide. Periaxin (Prx) is a scaffold protein interacting with membrane/cytoskeletal networks in the lens and other cell types and has been implicated in cataract development. My project will investigate the functions of Prx variants in lens cells. Recent studies in the Gong Lab suggest that Prx is a genetic modifier regulating cataract severity in connexin 46 knockout (Cx46KO) mice. Four Prx missense variants have been identified between the 129SvJae (129) and the C57BL/6J (B6) mouse strains. […]

Britney Weng

Profile image of Britney Weng

  In humans, Positive Transcription Elongation Factor b (P-TEFb) is an RNA Polymerase II regulator crucial for proper gene expression. To execute its regulatory function, P-TEFb itself is precisely regulated via reversible interactions with an snRNP complex. Using biochemical techniques, past studies have confirmed LARP7, HEXIM1, and BRD4 to be protein partners of P-TEFb. My project aims to study the dynamic regulatory role of known protein partners LARP7, HEXIM1, and BRD4 in P-TEFb regulation. I will apply a new technique called proximity-assisted photoactivation (PAPA) to single particle tracking (SPT) and […]

Katrina White

Profile image of Katrina White

  Psychedelics have been used medicinally for thousands of years by Native Americans, but research into their clinical effects and mechanisms was prematurely halted in the 1960s. Exploration of the effects of psychedelics is long overdue. Recent studies have found that single doses of psychedelics can have positive, long-lasting effects, but very few studies examine psychedelic effects on behavior. My project aims to discover how psychedelics influence associative learning behavior. Associative learning involves learning the association between a cue and an outcome. I hypothesize that mice treated with psychedelics will […]

Mihir Shah

Profile image of Mihir Shah

Glioblastoma (GBM) is the most common and lethal primary brain tumor in adults. Although research has enhanced GBM diagnosis and clinical stratification, overall patient outcome has not significantly improved. This is because GBM is incurable with current treatments, which include surgery, radiation therapy, and Temozolomide (TMZ) chemotherapy. The development of CRISPR-Cas9 systems presents opportunities to study human diseases, and it can be leveraged to create therapeutics. Specifically, CRISPR interference (CRISPRi)-based screens help study GBM dependencies and growth vulnerabilities without DNA damage. I have assisted with in vivo and in vitro […]