John Campo

The ultimate goal of my research is to identify the structure of the subunit of DNA polymerase III in Aquifex aeolicus (Aquifex) using X-ray crystallography. DNA pol III is the enzyme that is responsible for the majority of the DNA replication that occurs in this strain of bacteria. The the subunit of DNA pol III is responsible for the polymerase activity. To date, the structure of the replicative unit has only been determined in two gram-negative bacteria, Escherichia coli (E. coli) and Thermus aquaticus (Taq) (Lamers et al., 2006, and […]

Alexandra Carstensen

How does the brain represent concepts outside of perceptual experience? Relatively little is known about the neural mechanisms and brain areas involved in abstract thoughtthose enabling us to conceptualize domains for which we lack dedicated perceptual systems. Theories of embodied cognition suggest that understandings of such abstract domains are constructed from co-experienced perceptual input; for instance, Lakoff & Johnson (1999) have proposed that we build representations of time based on experiences of movement through space, as we consistently experience the passage of time while moving. This research seeks to determine […]

Cheong Chan

Physicists can now readily cool atoms down to near absolute zero and exploit their quantum behavior that one does not see at everyday room temperatures. One such application of cold atoms is called atom interferometry. Typically, the experimental setup of atom interferometers are quite bulky and can fill up a room. However, at the cost of some sensitivity these setups can be scaled down to the size of a moving box. Since such a small atom interferometers can measure accelerations nearly as well as other cutting edge technology, a miniature […]

Chryl Corbin

The Naturalization Act of 1870 ushered in a wave of immigration during the turn of the 20th century which included many from the West Indies. While they sought the same opportunities as their European counterparts they often suffered from, and organized against, discrimination and Jim Crow segregation. Thus as activists, intellectuals, and parents, these immigrants paved the way for their children who went on to become such civil rights pioneers as W.E.B. DuBois, James Weldon Johnson, Shirley Chisholm, and Malcolm X. My research illuminates how these often overlooked immigrants helped […]

Tianzan Zhou

My project concerns the regulation of transcription. Transcription is the process by which a DNA sequence is transcribed into an RNA sequence. This RNA sequence then gets translated into a protein, which is the basic machinery of life. Therefore, the mechanisms by which transcription is regulated are very important to understand. We have evidence for a novel mechanism that takes place during transcription and utilizes the creation of truncated, nonfunctional RNA transcripts of a gene to repress the formation of long, functional transcripts of that same gene. We do not […]

Lucas Zipp

Diamond magnetometry works by probing the electron spin resonances of the nitrogen-vacancy (NV) centers in diamond. An NV center is a defect in the diamond crystal structure in which a nitrogen atom is located next to a hole in the lattice structure. An external magnetic field causes a shift in the electron spin energy levels of the NV centers. Using lasers and microwaves, we can manipulate the electron quantum spin states to detect this shift. My goal this summer is to examine the NV defects in diamond with nanometer scale […]

Graham Shapiro

Does there exist a relationship between the times of past earthquakes and the time until the next earthquake? Recent research suggests that there exists patterns in earthquake occurrence that exist between long sequences of earthquakes. Most current earthquake models assume earthquakes are either memoryless or only incorporate short-term memory. The purpose of this research is to develop a statistical earthquake model that incorporates time-dependence as well as long-term memory. Specifically to create a computer implemented time dependant statistical model of temporal sequences of earthquake features to estimate the effect of […]

Maansi Shah

DivL is an essential protein in Caulobacter crescentus that acts upstream of the master cell-cycle regulator, CtrA. Sequence analysis shows DivL to be homologous to histidine protein kinases, however, it has a tyrosine at its active site rather than a histidine. DivL is an essential protein but a mutant form of the protein, in which autophosphorylation is prevented by the substitution of phenylalanine for the tyrosine at the phosphorylation site, is still capable of supporting viability. Thus, DivL activates CtrA by a mechanism other than phosphorylation. The goal of my […]

Marco Ponce

Derek Moriyama

My research is looking into the effects of chemical modification of the skeletal muscle protein troponin I. The troponin complex is composed of three subunits (troponin I, C, and T) that combine to regulate the strength of skeletal muscle contraction. Past research has shown that modification of troponin I by specific enzymes can increase the amount of force heart muscles produce. My project will focus on the effects of such enzymes in skeletal muscles. Because the structure of troponin I in skeletal muscle varies slightly from the structure found in […]