Shea Khyeam
Although animals such as zebrafish and newborn mice retain the ability to regenerate the heart post-injury, adult mammalians have largely lost this cardiac regenerative capacity. Consequently, a patient will irreversibly lose as many as a billion cardiomyocytes following a heart attack and suffer from permanently reduced cardiac function. Today, nearly five million Americans live with heart failurethis underscores the significance of our inability to regenerate myocardial tissue. Most mammalian cardiomyocytes lose their proliferative and regenerative abilities because they undergo binucleation, terminal differentiation, and permanent withdrawal from the cell cycle postnatally. […]
Amy Zhang
The precise regulation of gene expression programs is fundamental for all cellular processes. The control of gene expression involving transcriptional activation and/or transcriptional repression is achieved by highly specific protein complexes. The aim of my work is to understand the mechanistic details of the yeast transcription repressor, the SIR complex, which is made up of three proteins: Sir2, Sir3, and Sir4. The SIR complex is critical for the epigenetic regulation of gene expression and the maintenance of chromosome stability. The comparative analysis of the different mechanisms of transcription repression processes […]
Megan Sousa
Research on bacterial antibiotic resistance evolution has primarily been carried out in liquid culture; however, many infections are in the form of biofilms. Biofilms are composed of bacteria embedded in a complex matrix that protects pathogenic bacteria making them highly virulent, much more difficult to treat in patients, and an important focus of medical research. One interesting characteristic of biofilm growth is that genetically-identical cells can differentiate into multiple cell types, such as motile cells, which can swim within the biofilm. It is unclear how much these swimming cells can […]
Jasper Murphy
Bovine leukemia virus (BLV) is a retrovirus that is present in 84% of dairy and 38% of beef cattle in the USA [Buehring]. Even more threatening is the discovery that humans are also infected with BLV and the frequency of BLV DNA in mammary epithelium from women with breast cancer (59%) was significantly higher than in normal controls (29%) [Buehring]. This association of BLV with breast cancer motivates research toward generating a treatment. In my research project, I will attempt to knock out the essential tax region of the BLV […]
Aimee Cortez
The soil microbial community is rich with bacteria that provide an abundant source of medically valuable natural antibiotics and pharmaceuticals. In particular, Streptomyces padanus possesses antimicrobial activity and produces actinomycin D, an antibiotic with antitumor properties. However, there is a lack of understanding in the field regarding the ecology of antibiotic production in S. padanus — specifically how antibiotic products contribute to antimicrobial activity during microbial interactions. Preliminary data suggests that activity of actinomycin D inhibits growth of the fungus Metarhizium anisopliae during interspecies interactions. In my research, I will […]
Vivian Li
The firing properties of a neuron are not only influenced by the electrical and chemical signals it receives, but also by the physical properties of its environment. Their ability to detect stimuli such as pH, temperature, and mechanical pressure allows a neuron to change its excitability in response. Two-pore domain potassium (K2P) ion channels are of particular importance because they are crucial in hyperpolarizing and modulating the resting membrane potential. Deviations from normal resting membrane potentials lead to unexpected consequences, including mental illness.The purpose of this research project is to […]
Lucy Sandoe
My project will try to address the possible hazards associated with the Mendocino Triple Junction, where the Pacific, North American, and Gorda plates meet. This project will use Global Positioning Satellites (GPS) and python programs to measure and model ground deformation in order to further understand the uplift that results from the intersection of the three tectonic plates. These deformation models are a novel approach to characterize whether faulting, aseismic deformation, or deeper mantle processes cause uplift in different parts of the region. From this characterization, this project aims to […]
Andrew Chen
CRISPR-Cas9 is a versatile genome-editing technology that is widely used to modify genome sequences linked to genetic abnormalities. Often, the CRISPR-Cas9 system is used to target or repair disease-causing versions of genes, delete fragments of unwanted DNA, and insert therapeutic gene sequences to treat diseases. However, many studies have shown that CRISPR-Cas9 can cause unexpected mutations and genomic rearrangements in untargeted sites. My research aims to develop a self-inactivation system in effort to limit long-term expression of nuclease-editing protein Cas9 while still maximizing its on-target cuts and reducing off-target effects. […]
Dalila Robledo
The experiment that I will be working on this summer is currently being set up to prepare lithium-rubidium ultracold molecules. Ultracold molecules are those whose kinetic temperature as a measure of their velocity distribution is close to zero Kelvin, the regime where quantum effects of matter dominate. An interesting property of this particular molecule is its intrinsically large permanent dipole moment, which allows it to strongly interact with neighboring molecules. Strong tunable interactions allow for the realization of quantum entangling operations, so understanding and controlling molecular systems contributes to both […]
Zoe Adams
It has been shown that tumors are not simply genetically homogeneous collections of cells, but rather growths of evolving, genetically diverse populations that typically arise from a single mutant cell. As this mutant cell proliferates, its daughter cells naturally pick up more mutations due to a variety of factors, creating genetic heterogeneity. More and more studies have been published analyzing the possible interactions of these varied populations, ultimately suggesting that there may be cooperation that influences tumor growth. My lab at UCSF has developed a system using a 4-color confetti […]